The 159th Fighter Wing is a unit of the United States Air Force (USAF) part of the Pennsylvania Air National Guard. Established on September 24, 1946, it is headquartered at Syracuse Hancock International Airport in DeWitt, Onondaga County, New York. The primary mission of the 159th Fighter Wing involves the operation and maintenance of the F-15 Eagle fighter aircraft, providing air defense for the Northeastern United States. The wing also supports federal and state missions as required, including disaster response and humanitarian aid.